ABSTRACT
A 23-year-old man with no significant medical history was rushed to a hospital due to transient loss of consciousness with incontinence. The patient had developed a fever after his second dose of coronavirus disease 2019 (COVID-19) vaccine, and the patient was found groaning in bed approximately 40 hours after the vaccination in the early morning. The patient was diagnosed with Brugada syndrome (BrS) based on a drug-provocation test. His father had been diagnosed with BrS and died suddenly at 51 years of age. Young adults with a family history of BrS should be cautioned about fever following COVID-19 vaccination.
Subject(s)
Brugada Syndrome , COVID-19 Vaccines , COVID-19 , Adult , Humans , Male , Young Adult , Brugada Syndrome/diagnosis , Brugada Syndrome/etiology , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Electrocardiography , Fever , Syncope/etiologyABSTRACT
A 43-year-old man presented with cardiac arrest 2 days after the second coronavirus disease 2019 (COVID-19) vaccination with an mRNA vaccine. Electrocardiograms showed ventricular fibrillation and type 1 Brugada pattern ST segment elevation. The patient reported having no symptoms, including febrile sensation. There were no known underlying cardiac diseases to explain such electrocardiographic abnormalities. ST segment elevation completely disappeared in two weeks. Although there were no genetic mutations or personal or family history typical of Brugada syndrome, flecainide administration induced type 1 Brugada pattern ST segment elevation. This case suggests that COVID-19 vaccination may induce cardiac ion channel dysfunction and cause life threatening ventricular arrhythmias in specific patients with Brugada syndrome.
Subject(s)
Brugada Syndrome , COVID-19 , Male , Humans , Adult , Brugada Syndrome/diagnosis , Brugada Syndrome/etiology , Ventricular Fibrillation/diagnosis , Ventricular Fibrillation/etiology , COVID-19 Vaccines/adverse effects , Electrocardiography/adverse effects , Vaccination/adverse effectsSubject(s)
Brugada Syndrome , COVID-19 , Brugada Syndrome/diagnosis , Brugada Syndrome/etiology , Child , Electrocardiography , Humans , Phenotype , SARS-CoV-2ABSTRACT
A diagnosis of Brugada pattern in paediatric or adolescent patients is rare. COVID-19 is characterised by fevers and a pro-inflammatory state, which may serve as inciting factors for Brugada pattern. Recently described in two adult patients, we report the first case of Brugada pattern in an adolescent with COVID-19.